Gd-DTPA Enhanced Dynamic Renal MR Imaging of Experimentally.
10.3348/jkrs.1998.38.2.319
- Author:
Ik YANG
1
;
Soo Young CHUNG
;
Yul LEE
;
Kyung Won LEE
;
Mi Sook WON
;
Eil Seoung LEE
;
Kwan Sup LEE
;
Jung Woo NOH
;
Roh Won CHUN
;
Hyun Tae KIM
;
Moon Hyang PARK
Author Information
1. Department of Radiology, Hallym University College of Medicine.
- Publication Type:Original Article
- Keywords:
Animals;
Kidney, MR;
Nephritis
- MeSH:
Animals;
Biopsy;
Gadolinium DTPA*;
Glomerulonephritis;
Kidney;
Magnetic Resonance Imaging*;
Nephritis;
Rabbits
- From:Journal of the Korean Radiological Society
1998;38(2):319-327
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The purpose of this study was to evaluate the utility of Gd-DTPA-enhanced dynamic MRI (DMRI) in earlydiagnosis and the assessment of disease processing in experimentally-induced crescentic glomerulonephritis (CGN)in rabbits. MATERIALS AND METHODS: In six rabbits, CGN was induced by an injection of anti-glomerular basementmembrane Ab. A time-signal intensity curve (TSC) was obtained from DMRI on the day before, and at 1, 4, 7, 15, 45and 113 days after the induction of CGN. Sequential renal biopsies and blood sampling (serum creatinine) wereperformed on the same days, and the results of DMRI and TSC, were compared. RESULTS: In normal kidneys, sequentialDMRI demonstrated the intratubular passage of Gd-DTPA as an inwardly migrating, thin, dark, band pattern. On days1 and 4, the thin dark band appeared but was poorly defined and TSC revealed a delay in peak time. On days 7 and15, movement of the band was seen to be weak and slow, and there was no centripetal migration. The maximal signalintensity of TSC was delayed, and the curves declined very slowly. On days 45 and 113, the dark band pattern wasvery weak and slow, and again there was no centripetal migration. CONCLUSION: GD-DTPA-enhanced DMRI may be ofvalue in the evaluation of disease processing and the severity of CGN.
