Molecular variants of the FSH receptor exon 10 (Thr307Ala; A919G) in premature ovarian failure (POF) women by PCR-SSCP.
- Author:
Nam Keun KIM
;
Sook Hwan LEE
;
Yoon Sung NAM
;
Tae Jong SOHN
;
Sang Hee PARK
;
Chan PARK
;
Jung Jae KO
;
Kwang Yul CHA
- Publication Type:Original Article
- Keywords:
Premature ovarian failure (POF);
FSH receptor gene;
Missense mutation;
PCR-SSCP
- MeSH:
Exons*;
Female;
Humans;
Mutation, Missense;
Primary Ovarian Insufficiency*;
Receptors, FSH*
- From:Korean Journal of Obstetrics and Gynecology
2000;43(7):1144-1146
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: This study was performed to determine whether the FSH receptor mutation is present in infertile Korean patients with 46,XX premature ovarian failure (POF) women. METHODS: The variant of FSH receptor exon 10 in thirteen 46, XX idiopathic POF and 4 healthy fertile (control) women were studied. Missense mutation in Exon 10 was detected in POF patients and healthy fertile women by polymerase chain reaction-single stranded conformation polymorphism (PCR-SSCP). RESULTS: The variant types of FSH receptor exon 10 (Thr307Ala; A919G) were found in healthy fertile (control) and POF women. CONCLUSIONS: This mutation may not be specific in POF patients and further study is needed in fertile (control) and POF women.
