Perinatal transmission of hepatitis B virus and vaccination in high-risk neonates
- Author:
Dat Tuan Do
- Publication Type:Journal Article
- Keywords:
Hepatitis
- MeSH:
Hepatectomy;
Hepatic Veins;
Surgery, Plastic;
Liver Transplantation
- From:Journal of Preventive Medicine
2002;12(1):5-10
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
To study on 65 HBsAg positive mothers and 61 their newborns received differents dosages and types of hepatitis B vaccine at 0, 1, 2 months. HBeAg was detected in 25 (38.5%) mothers and all of them were HBV DNA positive. HBsAg and HBV DNA was detected in 19 (76%) and 23 (92%) respectively of the 25 cord blood from HBeAg positive mothers, while detected in 16 (40%) and 12 (30%) respectively of the 40 cord blood from HBeAg negative mothers. Testing at 6 months after completion of the vaccineation schedule, the failure risk (HBsAg positive) of vaccines for dosage of 2.5 g/ml is higher than others (5 g/ml and 10 g/ml). Hepatitis B vaccine with hepatitis B immune globulin or vaccine dosages of 5 and 10g alone may be recommended for high-risk neonates.
