Effects of Exercise on Affected and Unaffected Hindlimb Muscles in Rats with Neuropathic Pain Induced by Unilateral Peripheral Nerve Injury.
10.4040/jkan.2010.40.5.611
- Author:
Myoung Ae CHOE
1
;
Gyeong Ju AN
Author Information
1. College of Nursing, Seoul National University, Seoul, Korea. machoe@snu.ac.kr
- Publication Type:Original Article ; English Abstract ; Research Support, Non-U.S. Gov't
- Keywords:
Pain;
Exercise;
Muscular atrophy;
Muscle weight;
Muscle fiber
- MeSH:
Animals;
Body Weight;
Disease Models, Animal;
Eating;
Hindlimb/*physiology;
Male;
Muscle Fibers, Skeletal/*physiology;
Muscular Atrophy/etiology/physiopathology;
Neuralgia/*etiology;
Peripheral Nerves/*injuries;
*Physical Conditioning, Animal;
Rats;
Rats, Sprague-Dawley
- From:Journal of Korean Academy of Nursing
2010;40(5):611-619
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The purpose of this study was to examine the effects of exercise on muscle weight and Type I and II fiber cross-sectional area of affected and unaffected hindlimb muscles in rats with neuropathic pain induced by unilateral peripheral nerve injury. METHODS: Neuropathic pain was induced by ligation and cutting of the left L5 spinal nerve. Adult male Sprague-Dawley rats were randomly assigned to one of two groups: The Pain+Exercise (PE) group (n=21) and the Sham+Exercise (SE) group (n=20). All rats had 28 sessions of treadmill exercise at grade 10 for 30 minutes, twice/day at 10 m/min for 14 days. Body weight, food intake and activity were measured every day. At 15 days all rats were anesthetized and soleus, plantaris and gastrocnemius muscles were dissected. Muscle weight and Type I, II fiber cross-sectional area of the dissected muscles were measured. RESULTS: The PE group showed significant increases (p<.05), as compared to the SE group for body weight and total diet intake, muscle weight of the unaffected soleus and plantaris, and in Type I and II fiber cross-sectional area of unaffected three muscles and affected plantaris. CONCLUSION: Exercise for 14 days attenuates unaffected soleus, plantaris and gastrocnemius muscle atrophy in neuropathic pain model.
