Detection of human papillomavirus DNA using the polymerase chain reaction in paraffin-embedded biopsy specimens of condylomata acuminata.
- Author:
Suk Joo CHOI
;
Doo Chan MOON
;
Kyung Sool KWON
;
Tae Ahn CHUNG
- Publication Type:Original Article
- Keywords:
Condylomata Acuminata;
Polymerase Chain Reaction;
Human Papillomavirus
- MeSH:
Biopsy*;
Condylomata Acuminata*;
DNA*;
Human papillomavirus 16;
Human papillomavirus 6;
Humans*;
Polymerase Chain Reaction*
- From:Korean Journal of Dermatology
1993;31(4):508-516
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Condylomata acuminata is a sexually transmitted cisease which is caused by the human papillomavirus(HPV). The types of HPV causing condylomata acuminata are HPV 6,11,16,18. HPV 16 and 18 are related to anogenital carcinoma. OBJECTIVE: The goals of this study were to determine the types cif HPV in condylomata acuminata, and to investigate the relationship between condylomata acuminata and anogenital carcinoma. MEHTODS: Polymerase chain reaction and restriction fragment le igth polymorphisms were performed in the paraffin-embedded tissues of 17 cases of condylomata acciminata. RESULTS: HPV DNA was detected in all of 17 cases of condylomata accuminata tested. HPV 6 and 11 were found in 53% (9/17) and 41% (7/17) of the samples, respectiiely. HPV 16 and/or 18, which are related to anogenital carcinovia, were not detected, except in one case in which HPV 16 was found to be superimposed with HPV 6 and 11. CONCLUSION: These results suggest that most of condylomata acumirata are caused by HPV 16 and 11, and there is not so much risk of this disease transforming into the aiogenital carcinoma.
