APOE Polymorphism Is Associated with C-reactive Protein Levels but Not with White Blood Cell Count: Dong-gu Study and Namwon Study.
10.3346/jkms.2015.30.7.860
- Author:
Yong Woon YUN
1
;
Sun Seog KWEON
;
Jin Su CHOI
;
Jung Ae RHEE
;
Young Hoon LEE
;
Hae Sung NAM
;
Seul Ki JEONG
;
Kyeong Soo PARK
;
So Yeon RYU
;
Seong Woo CHOI
;
Hee Nam KIM
;
Jane A CAULEY
;
Min Ho SHIN
Author Information
1. Gwangju-Jeonnam Regional Cardiocerebrovascular Center, Chonnam National University Hospital, Gwangju, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
C-reactive Protein;
Apolipoprotein E;
Polymorphism, Genetic;
Inflammation
- MeSH:
Aged;
Apolipoproteins E/*genetics;
C-Reactive Protein/*metabolism;
Female;
Genetic Association Studies;
Genotype;
Humans;
Inflammation/*blood/immunology;
Leukocyte Count;
Male;
Middle Aged;
Polymerase Chain Reaction;
Polymorphism, Restriction Fragment Length;
Polymorphism, Single Nucleotide/genetics;
Prospective Studies;
Republic of Korea
- From:Journal of Korean Medical Science
2015;30(7):860-865
- CountryRepublic of Korea
- Language:English
-
Abstract:
We evaluated the association of the APOE polymorphism with serum C-reactive protein levels and white blood cell count in two large population-based studies in Korean. The datasets included the Dong-gu study (n = 8,893) and the Namwon Study (n = 10,032). APOE genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism. Multivariable linear regression analysis was performed to evaluate the relationship of APOE genotypes with C-reactive protein levels and white blood cell count with adjustments for age, sex, body mass index, smoking, diabetes, hypertension, and serum lipids. In the multivariate model, carriers of E3E4 or E4E4 genotype had significantly lower C-reactive protein levels compared with carriers of E3E3 genotype group (0.50 mg/L vs. 0.67 mg/L; 0.37 mg/L vs. 0.67 mg/L, respectively, for the Dong-gu Study and 0.47 mg/L vs. 0.66 mg/L; 0.45 mg/L vs. 0.66 mg/L, respectively, for the Namwon Study). However, there was no difference in white blood cell count among APOE genotypes. We found that the APOE E4 allele is associated with lower C-reactive protein levels, but not white blood cell count. Our results suggest that APOE genotype may influence C-reactive protein levels through non-inflammatory pathway.
