Tc-99m HMPAO SPECT in Olivopontocerebellar Atrophy.
- Author:
Sang Soo LEE
1
;
Byung Woo YOON
;
Jae Kyu ROH
;
Sang Eun KIM
;
Myung Chul LEE
Author Information
1. Department of Neurology, College of Medicine, Chungbuk National University.
- Publication Type:Original Article
- MeSH:
Atrophy;
Brain Stem;
Cerebellar Ataxia;
Cerebellum;
Diagnosis;
Diagnostic Tests, Routine;
Humans;
Magnetic Resonance Imaging;
Neuroimaging;
Olivopontocerebellar Atrophies*;
Perfusion;
Technetium Tc 99m Exametazime*;
Tomography, Emission-Computed, Single-Photon*
- From:Journal of the Korean Neurological Association
1992;10(3):324-330
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We studied local cerebral blood flow with Tc-99m HMPAO SPECT in 15 patients with olivopontocerebellar atrophy(OPCA) and 15 age-matched control subjects without neurological desease. The diagnosis of OPCA was based upon the history and physical findings and upon the exclusion of other cerebellar ataxia by means of laboratory investigations. Computed tomographic scan and MRI revealed some degree of atrophy of the cerebellum in most patient with OPCA, and many also had atrophy of the brain stem. SPECT studies in these patients revealed decreased cerebral blood flow in the cerebellum in comparison with the normal control subjects(p<0.001). Two patients with minimal atrophy or no structural changes in the cerebellum also showed decreased perfusion. Tc-99m HMPAO SPECT may be useful as a diagnostic test in patients with OPCA. Some instances suggest that Tc-99m HMPAO SPECT may show abnormal finding earlier than other neuroimaging methods.
