A Case of Muir-Torre Syndrome: Extra-ocular Sebaceous Carcinoma in a Patient with Breast Cancer.
- Author:
Myoung Shin KIM
1
;
Oun Jae PARK
;
Chong Hyun WON
;
Sung Eun CHANG
;
Mi Woo LEE
;
Jee Ho CHOI
;
Kee Chan MOON
Author Information
1. Department of Dermatology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. miumiu@amc.seoul.kr
- Publication Type:Case Report
- Keywords:
Mismatch repair;
Muir-Torre syndrome;
Sebaceous carcinoma;
Sebaceous neoplasm
- MeSH:
Breast;
Breast Neoplasms;
Colorectal Neoplasms;
DNA Mismatch Repair;
Humans;
Keratoacanthoma;
Mass Screening;
Muir-Torre Syndrome
- From:Korean Journal of Dermatology
2010;48(8):696-699
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Muir-Torre syndrome is defined by concurrent or sequential development of internal malignancy - most commonly colorectal cancer - and sebaceous neoplasm or multiple keratoacanthomas. Recent studies revealed it was caused by mutations in DNA mismatch repair genes, and suggested screening for mismatch repair gene defects may be of value for patients with Muir-Torre syndrome. We, herein, report a patient with Muir-Torre syndrome, who developed breast cancer and extra-ocular sebaceous carcinoma. In addition, we discussed our experience of immunohistochemical staining for mismatch repair protein with a review of the literature.
