A Case of Adult-onset Still's Disease in a Patient with Ankylosing Spondylitis Complicated with Crohn's Disease.
10.4078/jrd.2011.18.2.142
- Author:
You Jae KIM
1
;
Hwan Sung PARK
;
Su Jeong KIM
;
Sung Soo KIM
;
Yong Gil KIM
;
Chang Keun LEE
;
Bin YOO
Author Information
1. Division of Rheumatology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Adult-onset Still's disease;
Ankylosing spondylitis;
Sacroiliitis;
Crohn's disease
- MeSH:
Antirheumatic Agents;
Arthralgia;
Back Pain;
C-Reactive Protein;
Crohn Disease;
Erythrocytes;
Exanthema;
Ferritins;
Fever;
Humans;
Korea;
Liver;
Low Back Pain;
Lymphatic Diseases;
Necrosis;
Pharyngitis;
Sacroiliitis;
Spondylitis, Ankylosing;
Still's Disease, Adult-Onset;
Young Adult
- From:Journal of Rheumatic Diseases
2011;18(2):142-146
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Adult-onset Still's disease (AOSD) is an inflammatory disorder of unknown aetiology characterized by a variety of clinical symptoms. AOSD can precede or occur concomitantly with AS and only a few cases of AOSD with AS have been reported. A 21-year-old man presented with spiking fever, sore throat, arthralgia, maculopapular rash, lymphadenopathy, and chronic inflammatory back pain. His laboratory findings showed marked elevations of liver enzyme, C-reactive protein, erythrocyte sedimentatioin rate, ferritin, and sacroiliitis (grade 2), which were the main characteristics of AOSD and AS. Most symptoms except chronic low back pain were improved after treatment with corticosteroid and disease modifying anti-rheumatic drugs. He was then treated with anti-tumor necrosis factor-alpha (anti-TNF-alpha) agents to control the disease activity of AS and subsequently showed clinical and serological improvement. This is a first case report of AOSD combined with AS in Korea.
