Polymeric Gene Delivery for Diabetic Treatment.
10.4093/dmj.2011.35.4.317
- Author:
Sung Wan KIM
1
Author Information
1. Department of Pharmaceutics and Pharmaceutical Chemistry and Department of Bioengineering, University of Utah, Salt Lake City, UT, USA. SW.Kim@pharm.utah.edu
- Publication Type:Review
- Keywords:
Il-10 plasmid DNA;
GAD MRNA;
SP-Ex4;
FasSiRNA
- MeSH:
Animals;
Antigens, Neoplasm;
DNA;
Glutamate Decarboxylase;
Glycolates;
Histocompatibility Antigens;
Interleukin-10;
Mice;
Mice, Inbred NOD;
Plasmids;
Polyethylene Glycols;
Polylysine;
Polymers;
RNA, Messenger;
RNA, Small Interfering;
Transplants
- From:Diabetes & Metabolism Journal
2011;35(4):317-326
- CountryRepublic of Korea
- Language:English
-
Abstract:
Several polymers were used to delivery genes to diabetic animals. Polyaminobutyl glycolic acid was utilized to deliver IL-10 plasmid DNA to prevent autoimmune insulitis of non-obese diabetic (NOD) mouse. Polyethylene glycol grafted polylysine was combined with antisense glutamic acid decarboxylase (GAD) MRNA to represent GAD autoantigene expression. GLP1 and TSTA (SP-EX4) were delivered by bioreducible polymer to stop diabetic progression. Fas siRNA delivery was carried out to treat diabetic NOD mice animal.
