Helicobacter pylori Infection and Gastroduodenal Pathology in Children with Upper Gastrointestinal Symptoms.
- Author:
Young Ran YOON
1
;
Mi Ryeung KIM
;
Jae Young LIM
;
Myoung Bum CHOI
;
Chan Hoo PARK
;
Hyang Ok WOO
;
Hee Shang YOUN
;
Gyung Hyuck KO
;
Hyung Lyun KANG
;
Seung Chul BAIK
;
Woo Kon LEE
;
Myung Je CHO
;
Kwang Ho RHEE
Author Information
1. Department of Pediatrics, Gyeongsang National University College of Medicine, Jinju, Korea. hsyoun@nongae.gsnu.ac.kr
- Publication Type:Original Article
- Keywords:
Helicobacter pylori;
Urease test;
Immunoblotting;
Gastritis;
Child
- MeSH:
Abdominal Pain;
Antibodies;
Biopsy;
Child*;
Duodenal Ulcer;
Duodenitis;
Endoscopy;
Gastritis;
Helicobacter pylori*;
Helicobacter*;
Humans;
Hunger;
Hyperemia;
Immunoblotting;
Immunoglobulin G;
Nausea;
Pathology*;
Silver Staining;
Stomach Ulcer;
Urea;
Urease
- From:Korean Journal of Pediatric Gastroenterology and Nutrition
2003;6(2):103-111
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This study was undertaken to evaluate the gastroduodenal pathology and Helicobacter pylori infection in children with upper gastrointestinal symptoms. METHODS: One hundred and seven pediatric patients with upper gastrointestinal symptoms were undergone endoscopy at the Gyeongsang National University Hospital from June 1990 to April 1991. Histopathologic examination was done by H & E staining of gastric antral biopsy specimen and gastritis was defined according to the Sydney System. Tissue H. pylori status was evaluated with the urease test using Christensen's urea broth and H & E or Warthin-Starry silver staining of gastric antral biopsy specimen. IgG Immunoblotting were also performed to detect specific anti-H. pylori antibody in these patients. RESULTS: The reasons for endoscopy were recurrent abdominal pain, acute abdominal pain, sallow face, hunger pain, and frequent nausea. Variable degrees of gastric mucosal hyperemia were found in most of the patients. Gastric hemorrhagic spots, gastric ulcer, duodenal ulcer, duodenal erosion, and hemorrhagic duodenitis were rare endoscopic findings. Histologic chronic gastritis was found in 88% of 107 patients. Histologic chronic duodenitis was observed in all 99 patients whose tissue were available. Gastric tissue H. pylori was positive in 57% of 107 patients by one of the ureasetest, H & E staining and Warthin-Starry silver staining. However, gastric tissue H. pylori detection rate was lower in the younger age groups. Anti-H. pylori IgG antibodies were detectable in 96% of 107 patients. CONCLUSION: Chronic gastroduodenitis and anti-H. pylori IgG antibody were ubiquitous in children with upper gastrointestinal symptoms.
