Therapeutic Effect of Ketoconazole in Onychomycosis.
- Author:
Sung Nack LEE
;
Shin Won HAN
;
Dong Sik BANG
;
In Whan NAM
- Publication Type:Original Article
- MeSH:
Dyspepsia;
Fingers;
Griseofulvin;
Headache;
Humans;
Ketoconazole*;
Nails;
Onychomycosis*
- From:Korean Journal of Dermatology
1984;22(3):273-279
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This study was undertaken to evaluate the efficacy and safety of orally administered ketoconazole in the treatment of onychomycosis. Thirteen patients with onychomycoiis were selected for this study. For evaluation of ketoconazole efficacy twelve patients received a 200 mg tablet of ketoconazole daily and one patient received a. 10() mg tablet of ketoconazole daily. All patients were studied monthly clinically and mycologically by KOH mount and culture on Sabourauds medium. The results were as follows: 1. Seven(53.8%) of thirteen cases achieved remission, marked improvement occurred in three cases(23.1%) and moderate improvement occurred in three cases (23. 1 %). 2. The mean duration of remission or clinical improvement was 5 months for all lesions and toenail lesions(5. 4 months) took longer to heal than finger nail lesions (4 months). 3. One hundred percent of patient who previously failed to respond to griseofulvin were cured or clinically improved by ketoconazole. 4. Two patients cornplained of indigestion and one of headache. In our study, ketoconazole was highly effective in the treatment of onychomycosis.
