Clinical Model for Predicting Hepatocellular Carcinomas in Patients with Post-Sustained Virologic Responses of Chronic Hepatitis C: A Case Control Study.
- Author:
Qing Lei ZENG
1
;
Bing LI
;
Xue Xiu ZHANG
;
Yan CHEN
;
Yan Ling FU
;
Jun LV
;
Yan Min LIU
;
Zu Jiang YU
Author Information
- Publication Type:Original Article
- Keywords: Case-control studies; Chronic hepatitis C; He-patocellular carcinoma; Risk factors; Sustained virologic response
- MeSH: Area Under Curve; Carcinoma, Hepatocellular*; Case-Control Studies*; Diagnosis; Fibrosis; Hepatitis C, Chronic*; Hepatitis, Chronic*; Humans; Risk Factors; ROC Curve; Sensitivity and Specificity
- From:Gut and Liver 2016;10(6):955-961
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: No clinical model exists to predict the occurrence of hepatocellular carcinoma in sustained virologic response-achieving (HCC after SVR) patients with chronic hepatitis C (CHC). METHODS: We performed a case-control study using a clinical database to research the risk factors for HCC after SVR. A predictive model based on risk factors was established, and the area under the receiver operating characteristic curve (AUC) was calculated. RESULTS: In the multivariate model, an initial diagnosis of compensated cirrhosis and post-SVR albumin reductions of 1 g/L were associated with 21.7-fold (95% CI, 4.2 to 112.3; p<0.001) and 1.3-fold (95% CI, 1.1 to 1.7; p=0.004) increases in the risk of HCC after SVR, respectively. A predictive model based on an initial diagnosis of compensated cirrhosis (yes, +1; no, 0) and post-SVR albumin ≤36.0 g/L (yes, +1; not, 0) predicted the occurrence of HCC after SVR with a cutoff value of >0, an AUC of 0.880, a sensitivity of 0.833, a specificity of 0.896, and a negative predictive value of 0.956. CONCLUSIONS: An initial diagnosis of compensated cirrhosis combined with a post-SVR albumin value of ≤36.0 g/L predicts the occurrence of HCC after SVR in patients with CHC.
