Scanning Laser Polarimetry and Optical Coherence Tomography for Detection of Retinal Nerve Fiber Layer Defects.
10.3341/kjo.2009.23.3.169
- Author:
Jong Hyun OH
1
;
Yong Yeon KIM
Author Information
1. Department of Ophthalmology, National Medical Center, Seoul, Korea.
- Publication Type:Original Article ; Comparative Study
- Keywords:
Optical coherence tomography;
Red-free fundus photography;
Retinal nerve fiber layer defects;
Scanning laser polarimetry
- MeSH:
Adult;
Aged;
Cross-Sectional Studies;
Diagnostic Techniques, Ophthalmological;
Female;
Fundus Oculi;
Humans;
Male;
Middle Aged;
Nerve Fibers/*pathology;
Retina/*pathology;
Retrospective Studies;
*Scanning Laser Polarimetry;
*Tomography, Optical Coherence;
Young Adult
- From:Korean Journal of Ophthalmology
2009;23(3):169-175
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To compare the ability of scanning laser polarimetry with variable corneal compensation (GDx-VCC) and Stratus optical coherence tomography (OCT) to detect photographic retinal nerve fiber layer (RNFL) defects. METHODS: This retrospective cross-sectional study included 45 eyes of 45 consecutive glaucoma patients with RNFL defects in red-free fundus photographs. The superior and inferior temporal quadrants in each eye were included for data analysis separately. The location and presence of RNFL defects seen in red-free fundus photographs were compared with those seen in GDx-VCC deviation maps and OCT RNFL analysis maps for each quadrant. RESULTS: Of the 90 quadrants (45 eyes), 31 (34%) had no apparent RNFL defects, 29 (32%) had focal RNFL defects, and 30 (33%) had diffuse RNFL defects in red-free fundus photographs. The highest agreement between GDx-VCC and red-free photography was 73% when we defined GDx-VCC RNFL defects as a cluster of three or more color-coded squares (p<5%) along the traveling line of the retinal nerve fiber in the GDx-VCC deviation map (kappa value, 0.388; 95% confidence interval (CI), 0.195 to 0.582). The highest agreement between OCT and red-free photography was 85% (kappa value, 0.666; 95% CI, 0.506 to 0.825) when a value of 5% outside the normal limit for the OCT analysis map was used as a cut-off value for OCT RNFL defects. CONCLUSIONS: According to the kappa values, the agreement between GDx-VCC deviation maps and red-free photography was poor, whereas the agreement between OCT analysis maps and red-free photography was good.
