Membranous Nephropathy after Allogeneic Hematopoietic Stem Cell Transplantation in a Patient with Aplastic Anemia: A Case Report.
10.3346/jkms.2003.18.2.287
- Author:
Kee Won KIM
1
;
Chong Hyeon YOON
;
Chul Seung KAY
;
Hee Jung KIM
;
Kwang Sun SUH
;
Suk Young KIM
;
Suk Young PARK
Author Information
1. Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. kkw1965@chollian.net
- Publication Type:Case Report
- Keywords:
Graft vs Host Disease;
Nephrotic Syndrome;
Glomerulonephritis
- MeSH:
Adult;
Anemia, Aplastic*/physiopathology;
Anemia, Aplastic*/therapy;
Female;
Glomerulonephritis, Membranous/etiology*;
Glomerulonephritis, Membranous/pathology;
Graft vs Host Disease/physiopathology;
Hematopoietic Stem Cell Transplantation/adverse effects*;
Human;
Kidney Glomerulus/pathology
- From:Journal of Korean Medical Science
2003;18(2):287-289
- CountryRepublic of Korea
- Language:English
-
Abstract:
Nephrotic syndrome has been described as one of the clinical forms of chronic graft-versus-host disease (cGVHD), but a limited number of cases have been described. We experienced a young female patient with nephrotic syndrome developed 22 months after allogeneic hematopoietic stem cell transplantation (HSCT) for severe aplastic anemia. She had been well after successful management for gut-limited cGVHD until she developed a clinical nephrotic syndrome with hypoalbuminemia of 2.0 g/dL and 24-hr urine protein of 6.88 g/dL. On physical examination and laboratory findings, there was no other evidence of cGVHD. Clinical and renal biopsy findings were consistent with cGVHD-related membranous nephropathy, and immunosuppressive agents with cyclosporine and prednisone were prescribed. After 3 month of treatment, the proteinuria decreased to normal range; and the patient from nephrotic syndrome nearly recovered. We recommend cGVHD-related glomerulonephritis should be considered in all patients with hypoalbuminemia following allogeneic HSCT, even if there is no other evidence of clinical GVHD.
