First Male Case of Lymphocytic Hypophysitis in Korea.
10.3346/jkms.2003.18.2.290
- Author:
Hyun Kyung CHUNG
1
;
Doh Hyung KIM
;
Sang Jun KIM
;
Bong Jin PARK
;
Eo Jin KIM
;
Na Hye MYONG
;
Sang Jeon CHOI
Author Information
1. Department of Internal Medicine, College of Medicine, Dankook University, Cheonan, Korea. chkendo@dankook.ac.kr
- Publication Type:Case Report
- Keywords:
Autoimmune Diseases of the Nervous System;
Pituitary Gland;
Hypopituitarism;
Pituitary Diseases;
Brain Diseases
- MeSH:
Adult;
Autoimmune Diseases/diagnosis*;
Autoimmune Diseases/pathology;
Autoimmune Diseases/surgery;
Eosinophilia;
Female;
Human;
Korea;
Lymphocytes/cytology;
Lymphocytes/immunology*;
Lymphocytes/metabolism;
Magnetic Resonance Imaging;
Male;
Pituitary Diseases/diagnosis*;
Pituitary Diseases/pathology;
Pituitary Diseases/surgery;
Pituitary Gland/pathology*;
Pituitary Gland/surgery;
Pituitary Hormones/metabolism;
Pregnancy
- From:Journal of Korean Medical Science
2003;18(2):290-294
- CountryRepublic of Korea
- Language:English
-
Abstract:
Lymphocytic hypophysitis is a rare inflammatory disorder which is caused by autoimmune destruction of the pituitary gland. Almost all reported cases have been in women and the disease is often associated with pregnancy. We describe here the first male case of lymphocytic hypophysitis in Korea. The patient presented with headache, impotence, decreased libido, and deteriorated vision. Endocrinologic studies showed panhypopituitarism, and pituitary MRI imaging revealed a homogeneously enhanced pituitary mass with a thickened stalk. Treatment with prednisolone and thyroid hormone for five months was ineffective. Transsphenoidal resection of the pituitary mass was performed successfully with normalization of the visual field defect. Histologic examination revealed diffuse lymphocytic infiltration with dense collagenous fibrosis, consistent with lymphocytic hypophysitis. Lymphocytic hypophysitis should be considered in differential diagnosis even in men with hypopituitarism and an enlarged pituitary gland.
