Malignant Transformation of Intrathoracic Ancient Neurilemmoma in a Patient without Von Recklinghausen's Disease.
10.3346/jkms.2003.18.2.295
- Author:
Young Chae CHU
1
;
Yong Han YOON
;
Hye Seung HAN
;
Jee Young HAN
;
Joon Mee KIM
;
In Suh PARK
Author Information
1. Department of Anatomical Pathology, Inha University Hospital, Incheon, Korea. ycchu@inha.ac.kr
- Publication Type:Case Report
- Keywords:
Neurilemmoma;
Cell Transformation, Neoplastic;
Neoplastic Processes
- MeSH:
Adult;
Cell Transformation, Neoplastic*;
Diagnosis, Differential;
Human;
Male;
Neurilemmoma/complications;
Neurilemmoma/pathology*;
Neurofibromatosis 1/complications;
Neurofibromatosis 1/pathology*;
Thoracic Neoplasms/etiology;
Thoracic Neoplasms/pathology*;
Tumor Markers, Biological
- From:Journal of Korean Medical Science
2003;18(2):295-298
- CountryRepublic of Korea
- Language:English
-
Abstract:
Malignant transformation of a neurilemmoma is an exceedingly rare event. We describe a case of intrathoracic ancient neurilemmoma undergoing a malignant change in a 39-yr-old man. The patient presented with right flank and chest pain for several months. Plain radiography and CT scan of the chest showed a soft tissue mass lesion at the extrapleural space with erosion of surrounding ribs at the right basal lung area. The excised mass was encapsulated and measured 4.5 x 3.5 x 2.3 cm. The cut surface showed grayish-white and glistening with a focal cystic change and hemorrhage. Necrosis was not seen. Histologically, the tumor showed the features of classic neurilemmoma composed of the Antoni type A and B areas with perivascular hyalinization. In addition, obviously histo-logically malignant foci manifested by presence of markedly increased cellularity with fascicular arrangement, active mitotic activity, hyperchromasia, and gradual loss of original neurilemmomatous feature were noted.
