Flumazenil-induced Ballism.
10.3346/jkms.2003.18.2.299
- Author:
Joong Seok KIM
1
;
Seok Bum KO
;
Yeong Bin CHOI
;
Kwang Soo LEE
Author Information
1. Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea. ks1007@cmc.cuk.ac.kr
- Publication Type:Case Report
- Keywords:
Ballism;
Flumazenil;
GABA;
Dopamine
- MeSH:
Diagnosis, Differential;
Dyskinesias/etiology*;
Female;
Flumazenil/adverse effects*;
GABA Modulators/adverse effects*;
Human;
Middle Aged
- From:Journal of Korean Medical Science
2003;18(2):299-300
- CountryRepublic of Korea
- Language:English
-
Abstract:
Flumazenil, an imidazobenzodiazepine, is the first benzodiazepine antagonist and is being used to reverse the adverse pharmacological effects of benzodiazepine. There have been a few reports on the central nevous system side effects with its use. We report a patient with generalized ballism following administration of flumazenil. The mechanism through which flumazenil induced this symptom is unknown. It is conceivable that flumazenil may antagonize the GABA-benzodiazepine receptor complex and induce dopamine hypersensitivity, thus induce dyskinesic symptoms.
