Risk Factors for Mortality in Patients with Serratia marcescens Bacteremia.
10.3349/ymj.2015.56.2.348
- Author:
Sun Bean KIM
1
;
Yong Duk JEON
;
Jung Ho KIM
;
Jae Kyoung KIM
;
Hea Won ANN
;
Heun CHOI
;
Min Hyung KIM
;
Je Eun SONG
;
Jin Young AHN
;
Su Jin JEONG
;
Nam Su KU
;
Sang Hoon HAN
;
Jun Yong CHOI
;
Young Goo SONG
;
June Myung KIM
Author Information
1. Division of Infectious Disease, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. smileboy9@yuhs.ac
- Publication Type:Original Article
- Keywords:
Serratia marcescens;
bacteremia;
mortality;
risk factors
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Anti-Bacterial Agents/therapeutic use;
Bacteremia/drug therapy/microbiology/*mortality;
Cross Infection/mortality;
Female;
Humans;
Intensive Care Units;
Male;
Middle Aged;
Multiple Organ Failure;
Republic of Korea/epidemiology;
Retrospective Studies;
Risk Factors;
Serratia Infections/diagnosis/drug therapy/*mortality;
Serratia marcescens/drug effects/*isolation & purification;
Severity of Illness Index;
Survival Rate;
Time Factors;
Treatment Outcome
- From:Yonsei Medical Journal
2015;56(2):348-354
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Over the last 30 years, Serratia marcescens (S. marcescens) has emerged as an important pathogen, and a common cause of nosocomial infections. The aim of this study was to identify risk factors associated with mortality in patients with S. marcescens bacteremia. MATERIALS AND METHODS: We performed a retrospective cohort study of 98 patients who had one or more blood cultures positive for S. marcescens between January 2006 and December 2012 in a tertiary care hospital in Seoul, South Korea. Multiple risk factors were compared with association with 28-day all-cause mortality. RESULTS: The 28-day mortality was 22.4% (22/98 episodes). In a univariate analysis, the onset of bacteremia during the intensive care unit stay (p=0.020), serum albumin level (p=0.011), serum C-reactive protein level (p=0.041), presence of indwelling urinary catheter (p=0.023), and Sequential Oran Failure Assessment (SOFA) score at the onset of bacteremia (p<0.001) were significantly different between patients in the fatal and non-fatal groups. In a multivariate analysis, lower serum albumin level and an elevated SOFA score were independently associated with 28-day mortality [adjusted odds ratio (OR) 0.206, 95% confidential interval (CI) 0.044-0.960, p=0.040, and adjusted OR 1.474, 95% CI 1.200-1.810, p<0.001, respectively]. CONCLUSION: Lower serum albumin level and an elevated SOFA score were significantly associated with adverse outcomes in patients with S. marcescens bacteremia.
