KAAACI Standardization Committee Report on the procedures and applications of the diagnostic tests for drug allergy.
10.4168/aard.2017.5.5.239
- Author:
Min Suk YANG
1
;
Ga Young BAN
;
Min Hye KIM
;
Kyung Hwan LIM
;
Hyouk Soo KWON
;
Woo Jung SONG
;
Jae Woo JUNG
;
Jeongmin LEE
;
Dong In SUH
;
Jae Woo KWON
;
Sae Hoon KIM
;
Yoo Seob SHIN
;
Hye Ryun KANG
;
Tae Bum KIM
;
Byung Jae LEE
;
Ai Young LEE
;
Hae Sim PARK
;
Sang Heon CHO
Author Information
1. Department of Internal Medicine, Seoul Metropolitan Government - Seoul National University Boramae Medical Center, Seoul, Korea.
- Publication Type:Review
- Keywords:
Drug hypersensitivity;
Skin tests;
Intradermal tests;
Patch tests
- MeSH:
Allergy and Immunology;
Asthma;
Consensus;
Diagnostic Tests, Routine*;
Drug Hypersensitivity*;
Humans;
Hypersensitivity;
In Vitro Techniques;
Intradermal Tests;
Patch Tests;
Skin;
Skin Tests
- From:Allergy, Asthma & Respiratory Disease
2017;5(5):239-247
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Diagnostic methods for drug allergy include the patient's history, in vivo skin test, in vitro laboratory test, and provocation test. However, the history is often not reliable, procedures for in vivo and in vitro tests are not standardized, and provocation tests are sometimes harmful to patients. Generally, skin prick and intradermal tests are useful for immediate reactions; in contrast, patch test and delayed reading of both skin prick and intradermal tests are helpful for delayed reactions. A drug provocation test is the gold standard for both responses, and it is necessary to be aware of exact indications and contraindications with appropriate drugs, doses, and intervals. To date, several methods have been developed to detect culprit agents for drug hypersensitivity reactions, but they are neither completely well validated nor standardized. Based on this awareness and necessity, the Korean Academy of Asthma, Allergy and Clinical Immunology launched the Standardization Committee to review the international guidelines and the literature, and then developed the consensus report on the procedures and applications of diagnostic tests for drug allergy.
