A case of oral desensitization for hypersensitivity to exogenous progesterone.
10.4168/aard.2017.5.5.294
- Author:
Young Chan KIM
1
;
Kook Hwan CHOI
;
Dong Yoon KANG
;
Kyung Hee SOHN
;
Sang Heon CHO
;
Kyung Up MIN
;
Hye Ryun KANG
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. helenmed@snu.ac.kr
- Publication Type:Case Report
- Keywords:
Progesterone;
Drug hypersensitivity;
Fertilization in vitro;
Immunologic desensitization
- MeSH:
Adult;
Autoimmunity;
Dermatitis;
Desensitization, Immunologic;
Diagnosis;
Drug Hypersensitivity;
Female;
Fertilization in Vitro;
Humans;
Hypersensitivity*;
Intradermal Tests;
Methods;
Progesterone*;
Urticaria
- From:Allergy, Asthma & Respiratory Disease
2017;5(5):294-297
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hypersensitivity reaction to progesterone is a rare pathologic condition which consists of autoimmune response to endogenous progesterone, known as autoimmune progesterone dermatitis, and hypersensitivity reaction to exogenous progestogen. We report the case of a 31-year-old woman with a history of whole body urticaria during exogenous progesterone supplementation for in vitro fertilization (IVF). She was admitted to the hospital for the diagnosis and management of progestogen hypersensitivity. An intradermal test with progesterone revealed positivity to 5 mg/mL of progesterone. For her next IVF, progesterone desensitization was performed in a method combining oral and intramuscular progesterone administration. After successfully achieving a target dose of 100 mg per day, the route of progesterone administration was converted to intravaginal tablet (90 mg twice a day) without any hypersensitivity reactions.
