Baicalein Protects Human Skin Cells against Ultraviolet B-Induced Oxidative Stress.
10.4062/biomolther.2016.022
- Author:
Min Chang OH
1
;
Mei Jing PIAO
;
Pattage Madushan Dilhara Jayatissa FERNANDO
;
Xia HAN
;
Susara Ruwan Kumara Madduma HEWAGE
;
Jeong Eon PARK
;
Mi Sung KO
;
Uhee JUNG
;
In Gyu KIM
;
Jin Won HYUN
Author Information
1. School of Medicine, Jeju National University, Jeju 63243, Republic of Korea. jinwonh@jejunu.ac.kr
- Publication Type:Original Article
- Keywords:
Baicalein;
Ultraviolet B;
Oxidative stress;
Reactive oxygen species;
HaCaT cells
- MeSH:
Apoptosis;
Cell Death;
Cell Line;
DNA Breaks;
Humans*;
Keratinocytes;
Oxidative Stress*;
Reactive Oxygen Species;
Scutellaria baicalensis;
Skin*
- From:Biomolecules & Therapeutics
2016;24(6):616-622
- CountryRepublic of Korea
- Language:English
-
Abstract:
Baicalein (5,6,7-trihydroxy-2-phenyl-chromen-4-one) is a flavone, a type of flavonoid, originally isolated from the roots of Scutellaria baicalensis. This study evaluated the protective effects of baicalein against oxidative damage-mediated apoptosis induced by ultraviolet B (UVB) radiation in a human keratinocyte cell line (HaCaT). Baicalein absorbed light within the wavelength range of UVB. In addition, baicalein decreased the level of intracellular reactive oxygen species (ROS) in response to UVB radiation. Baicalein protected cells against UVB radiation-induced DNA breaks, 8-isoprostane generation and protein modification in HaCaT cells. Furthermore, baicalein suppressed the apoptotic cell death by UVB radiation. These findings suggest that baicalein protected HaCaT cells against UVB radiation-induced cell damage and apoptosis by absorbing UVB radiation and scavenging ROS.
