Phenobarbital dosage and blood level for control of neonatal seizure.
- Author:
Hye Soon KIM
;
Keun LEE
;
Young Sook KO
- Publication Type:Original Article
- Keywords:
Neonatal convulsion;
Phenobarbital
- MeSH:
Anticonvulsants;
Humans;
Infant, Newborn;
Phenobarbital*;
Plasma;
Seizures*
- From:Journal of the Korean Pediatric Society
1993;36(12):1641-1646
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Twenty-five neonates were observed for the relationship between phenobrbital loading dose, plasma concentrations and control of seizures. Nineteen neonates (76%) had seizures controlled by phenobarbital alone. Effective plasma concentration were 10.0~31.1microgram/ml. Although 14 neonates had seizures controlled by phenobarbital concentration below 20microgram/ml, neonate required level above 30microgram/ml. We found that continued benefit was obtained until phenobarbital plasma concentrations reached 40microgram/ml and there was no adverse effects on cardiorespiratory function. We recommend that plasma phenobarbital concentrations should equal or surpass 40microgram/ml before additional anticonvulsants are used for neonates with seizure.
