Clinical Study of Ocular Adnexal Extranodal Marginal Zone B-cell Lymphoma: From the Perspective of Dermatology.
- Author:
Hyung Min LEE
1
;
Cheolwon SUH
;
Ho Seok SA
;
Chong Hyun WON
;
Sung Eun CHANG
;
Mi Woo LEE
;
Jee Ho CHOI
;
Kee Chan MOON
Author Information
1. Department of Dermatology, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea. miumiu@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Marginal zone B-cell lymphoma;
Ocular adnexal extranodal marginal zone B-cell lymphoma
- MeSH:
B-Lymphocytes;
Conjunctiva;
Dermatology;
Female;
Follow-Up Studies;
Humans;
Lymphoma, B-Cell, Marginal Zone;
Male;
Medical Records;
Orbit;
Recurrence;
Retrospective Studies
- From:Korean Journal of Dermatology
2012;50(5):403-412
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The ocular adnexal extranodal marginal zone B-cell lymphoma has been known as the 2nd most common extranodal marginal zone B-cell lymphoma, which presents as the dermatologic symptom and sign, such as orbital mass and swelling. However, the ocular adnexal extranodal marginal zone B-cell lymphoma has been few reported in the dermatologic literature. OBJECTIVE: We described the clinical and histopathological features of ocular adnexal extranodal marginal zone B-cell lymphoma from the perspective of dermatology. METHODS: Ninety-nine cases of ocular adnexal extranodal marginal zone B-cell lymphoma patients were included in this study, among the 352 patients, who were diagnosed with extranodal marginal zone B-cell lymphoma between March 1998 and February 2011. Their medical records and histopathologic slides were retrospectively reviewed. RESULTS: Among the 352 patient of extranodal marginal zone B-cell lymphoma, ocular adnexal extranodal marginal zone B-cell lymphoma occurred in 99 patients (28.1%). The ratio between male and female was 1:2, and the mean age was 50 years (range; 20~54 years). Ocular adnexal extranodal marginal zone B-cell lymphoma presented as orbital mass (39.1%), conjunctival injection (25.6%), orbital swelling (19.5%), and etc. In most patients, lesions were located in conjunctiva (63.8%) or orbit (14.5%). 76.7% of patients presented with Ann Arbor stage I disease. Relapses occurred in 8.4% of patients during the follow-up period. CONCLUSION: When dermatologists meet patients presenting with orbital mass and swelling, dermatologists consider the possibility of ocular adnexal extranodal marginal zone B-cell lymphoma and consultation with the ophthalmologists.
