Clinical Evaluation of a New-Formula Shampoo for Scalp Seborrheic Dermatitis Containing Extract of Rosa centifolia Petals and Epigallocatechin Gallate: A Randomized, Double-Blind, Controlled Study.
- Author:
Yu Ri KIM
1
;
Jeong Hwan KIM
;
Hong Ju SHIN
;
Yong Beom CHOE
;
Kyu Joong AHN
;
Yang Won LEE
Author Information
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords: Ellagitannins; Epigallocatechin gallate; Ketoconazole; Seborrheic dermatitis; Zinc pyrithione
- MeSH: Antifungal Agents; Dermatitis, Seborrheic*; Erythema; Humans; Hydrolyzable Tannins; Ketoconazole; Malassezia; Rosa*; Scalp*; Sebum; Skin Diseases; Surveys and Questionnaires
- From:Annals of Dermatology 2014;26(6):733-738
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Scalp seborrheic dermatitis is a chronic type of inflammatory dermatosis that is associated with sebum secretion and proliferation of Malassezia species. Ketoconazole or zinc-pyrithione shampoos are common treatments for scalp seborrheic dermatitis. However, shampoos comprising different compounds are required to provide patients with a wider range of treatment options. OBJECTIVE: This study was designed to evaluate a new-formula shampoo that contains natural ingredients-including extract of Rosa centifolia petals and epigallocatechin gallate (EGCG)-that exert antioxidative, anti-inflammatory, and sebum secretion inhibitory effects, and antifungal agents for the treatment of scalp seborrheic dermatitis. METHODS: Seventy-five patients were randomized into three treatment groups; new-formula shampoo, 2% ketoconazole shampoo, and 1% zinc- pyrithione shampoo. The clinical severity scores and sebum levels were assessed by the same dermatologists at baseline (week 0), and at 2 and 4 weeks after using the shampoo. User satisfaction and irritation were also assessed with the aid of a questionnaire. RESULTS: The efficacy of the new-formula shampoo was comparable to that of both the 1% zinc-pyrithione shampoo and the 2% ketoconazole shampoo. Furthermore, it was found to provide a more rapid response than the 1% zinc-pyrithione shampoo for mild erythema lesions and was associated with greater user satisfaction compared with the 2% ketoconazole shampoo. However, the new-formula shampoo did not exhibit the previously reported sebum inhibitory effect. CONCLUSION: Extract of R. centifolia petals or EGCG could be useful ingredients in the treatment of scalp seborrheic dermatitis.