Regulation of Obesity and Non-alcoholic Fatty Liver Diseases by Modulation of the Gut Microbiota Through Inflammasome; its Mechanism and Potential for Clinical Use.
10.4167/jbv.2012.42.4.359
- Author:
Jae Hwan NAM
1
Author Information
1. Department of Biotechnology, The Catholic University of Korea, Bucheon, Korea. jhnam@catholic.ac.kr
- Publication Type:Letter
- Keywords:
Inflammasome;
Gut microbiota;
Dysbiosis;
NAFLD;
NASH
- MeSH:
Colonic Neoplasms;
Fatty Liver;
Humans;
Inflammatory Bowel Diseases;
Metagenome;
Obesity
- From:Journal of Bacteriology and Virology
2012;42(4):359-362
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The revelation that gut microbes are associated with the pathogenesis of human diseases such as obesity, colon cancer, inflammatory bowel disease and liver-related diseases has resulted in the role of gut microbes becoming a novel research topic in basic and clinical science. Recently, emphasis has been placed on the role of gut microbes in non-alcoholic fatty liver disease (NAFLD) and its progressive form, non-alcoholic steatohepatitis (NASH). Researchers have suggested that inflammasome deficiency-changed dysbiosis is associated with exacerbating NAFLD/NASH progression. This particular study also showed a direct 'gut-liver axis' regulated by modulation of gut microbiota. This paper (Nature 2012;482: 179-185) was summarized herein and the potential clinical applications were discussed.
