A Novel PA-X Protein Translated from Influenza A Virus Segment 3.
10.4167/jbv.2012.42.4.368
- Author:
Ilseob LEE
1
;
Jin Il KIM
;
Man Seong PARK
Author Information
1. Department of Microbiology, College of Medicine, Hallym University, Chuncheon, Gangwon-do, Korea. manseong.park@gmail.com
- Publication Type:Letter
- Keywords:
Influenza;
Endonuclease activity;
Pathogenicity;
PA-X;
Ribosomal frameshift
- MeSH:
Animals;
Cells, Cultured;
Frameshifting, Ribosomal;
Gene Expression;
Influenza A virus;
Influenza, Human;
Mice
- From:Journal of Bacteriology and Virology
2012;42(4):368-371
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The pathogenicity of influenza A viruses is a multigenic trait, which is orchestrated by the global networks between eight viral genomic constituents and their cellular interacting partners. A recent report provided information on the finding of a new PA ribosomal frameshifting product, the PA-X protein, in the influenza A virus segment 3, and an endonuclease property was suggested for a possible role of the PA-X protein. In cultured cells, viral growth was not affected by the PA-X protein expression. However, the reduced pathogenicity of mice appeared to be closely associated with the PA-X protein expression. It was also revealed that the PA-X protein was able to modulate host gene expression. Considered together, the PA-X protein can be a cellular signaling modulator and subsequently control viral pathogenicity. By reviewing recent publications, we present new insights in the contribution of the PA-X protein to the cellular signaling network and the resultant viral pathogenicity.
