Nasopharyngeal Pneumococcal Carriage of Children Attending Day Care Centers in Korea: Comparison between Children Immunized with 7-valent Pneumococcal Conjugate Vaccine and Non-immunized.
10.3346/jkms.2011.26.2.184
- Author:
Kyung Hyo KIM
1
;
Jung Yun HONG
;
Hyunju LEE
;
Ga Young KWAK
;
Chan Hee NAM
;
Soo Young LEE
;
Eunsang OH
;
Jigui YU
;
Moon H NAHM
;
Jin Han KANG
Author Information
1. Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, Korea.
- Publication Type:Original Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
- Keywords:
Streptococcus pneumoniae;
Heptavalent Pneumococcal Conjugate Vaccine;
Epidemiology;
Child Day Care Centers
- MeSH:
Adult;
Carrier State/*immunology/prevention & control;
Child;
*Child Day Care Centers;
Child, Preschool;
Humans;
*Immunization;
Infant;
Male;
Microbial Sensitivity Tests;
Nasopharynx;
Pneumococcal Infections/*epidemiology/immunology/*prevention & control;
Pneumococcal Vaccines/*administration & dosage;
Prospective Studies;
Republic of Korea/epidemiology;
Serotyping;
Streptococcus pneumoniae/*isolation & purification
- From:Journal of Korean Medical Science
2011;26(2):184-190
- CountryRepublic of Korea
- Language:English
-
Abstract:
To confirm the effect of 7-valent pneumococcal conjugate vaccine (PCV7), pneumococcal nasopharyngeal (NP) carriage was compared between vaccinated (3 + 1 doses PCV7) and non-vaccinated children. Vaccinated subjects were recruited from highly vaccinated regions (> or = 60%), Seoul and Incheon whereas control subjects were recruited from Jeju Island where vaccination rates are low (< 15%). NP swabs were obtained from 400 children aged 18-59 months. Serotype and antibiotic susceptibility was analyzed. Pneumococcal carriage rate was 18.0% (36/200) and 31.5% (63/200) for the vaccinated and control group, respectively. Among those vaccinated, 41.7% (15/36) of the serotypes were vaccine-related type (VRT: 6A, 6C, 19A) with the most common serotype 6C. The next common type was non-typable/non-capsule 30.6% (11/36) followed by non-vaccine type 16.7% (6/36) and vaccine type (VT) serotypes were found in only 11.1% (4/36). In contrast, 52.4% (33/63) of the isolates in the control group were VT. Resistance rates for penicillin and erythromycin were lower in the vaccine group (vaccine vs control; penicillin 45.2% vs 71.4%, erythromycin 74.2% vs 90.5%, P < 0.05). Multi-drug resistance was also lower in vaccinated subjects (vaccine vs control; 45.2% vs 69.8%, P < 0.05). PCV7 reduces carriage in VT which leads to replacement of pneumococci by antibiotic susceptible VRT or non-vaccine type strains.
