The Diagnosis of Acute Antibody-Mediated Rejection in ABO-Incompatible Liver Transplants.
10.4285/jkstn.2012.26.1.6
- Author:
Ghee Young KWON
1
Author Information
1. Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. geeo@skku.edu
- Publication Type:Review
- Keywords:
ABO-incompatible;
Transplantation;
Liver;
Acute antibody-mediated rejection;
C4d
- MeSH:
Diagnosis, Differential;
Early Diagnosis;
Liver;
Liver Transplantation;
Rejection (Psychology);
Transplants
- From:The Journal of the Korean Society for Transplantation
2012;26(1):6-9
- CountryRepublic of Korea
- Language:English
-
Abstract:
Liver transplantation (LT) across the ABO-blood type barrier is prone to antibody-mediated rejection (AMR), which often leads to a deleterious clinical outcome. While it is of paramount importance to make an early diagnosis of AMR, the morphologic features of AMR in the liver are not specific, and the differential diagnosis is often difficult or even impossible on a morphologic basis alone. The clinical utility of C4d immunostaining is limited in the liver, unlike other organs, further complicating the situation. Therefore, the diagnosis of AMR in the liver requires integration of clinical, morphologic, immunopathologic, and serological evidence.
