A Case of Carbamazepine-induced Acute Interstitial Nephritis.
- Author:
Hyun Won SHIN
1
;
Jong Yeop KIM
;
Seung Myung MOON
;
Woo Yung JANG
;
Jang Won SEO
Author Information
1. Department of Internal Medicine, College of Medicine, Hallym University, Seoul, Korea. sjwdr@hanmail.net
- Publication Type:Case Report
- Keywords:
Acute interstitial nephritis;
Carbamazepine;
Acute renal failure
- MeSH:
Acute Kidney Injury;
Biopsy;
Carbamazepine;
Creatinine;
Exanthema;
Female;
Fever;
Gallium;
Humans;
Inflammation;
Meningioma;
Middle Aged;
Nephritis, Interstitial*;
Neutrophils;
Seizures;
Ultrasonography;
Valproic Acid
- From:Korean Journal of Nephrology
2005;24(3):470-474
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report a case of acute interstitial nephritis associated with carbamazepine in a 45-year-old woman who developed acute renal failure. The patient has been taken valproic acid and carbamazepine to control the recurrent episodes of seizure after the surgery for meningioma. The patient developed acute renal failure with fever and skin rash. The patient stopped all medications except valproic acid, and was examined by ultrasonography, gallium scan and renal biopsy. Renal biopsy revealed severe interstitial infiltration of neutrophils in glomeruli without inflammation. After discontinuation of carbamazepine, acute renal failure of the patient improved and serum creatinine returned to normal.
