A Case of Pure Red Cell Aplasia Due to Parvovirus B19 Infection in a Renal Transplant Recipient.
- Author:
Hyo Jin OH
1
;
Jong Woon CHEON
;
Dong Jik AHN
;
Sang Gyung KIM
;
Ki Sung AHN
;
In Hee LEE
Author Information
1. Department of Internal Medicine, School of Medicine, Catholic University of Daegu, Korea. ihlee@cu.ac.kr
- Publication Type:Case Report
- Keywords:
Pure red cell aplasia;
Parvovirus B19;
Kidney transplantation
- MeSH:
Adult;
Anemia;
Bone Marrow;
Cyclosporine;
DNA;
Erythroblasts;
Erythrocyte Transfusion;
Erythropoietin;
Glomerulonephritis;
Humans;
Immunoglobulin M;
Immunoglobulins;
Intranuclear Inclusion Bodies;
Kidney Failure, Chronic;
Kidney Transplantation;
Male;
Parvovirus*;
Polymerase Chain Reaction;
Prednisolone;
Red-Cell Aplasia, Pure*;
Renal Dialysis;
Tacrolimus;
Transplantation*
- From:Korean Journal of Nephrology
2005;24(3):494-500
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report a case of pure red cell aplasia due to parvovirus B19 infection in a renal transplant recipient. The patient was a 32-year-old male with end stage renal disease due to chronic glomerulonephritis, who had been undergoing regular hemodialysis. He received a living nonrelated renal transplant and immumosuppressive therapy including prednisolone, tacrolimus, and mycophenolate mofetil. One week after kidney transplantation, severe anemia was persisted despite recombinant human erythropoietin administration and packed red blood cell transfusion. His bone marrow aspiration smear demonstrated erythroid hypoplasia and giant pronormoblasts with prominent intranuclear inclusions. Both serum and bone marrow were positive for parvovirus B19 DNA polymerase chain reaction and anti-parvovirus B19 IgM. He was treated with intravenous immunoglobulin and conversion of tacrolimus to cyclosporine. His hemoglobin level was completely recovered three months later.
