Four Cases of Verapamil Deleterious Effects in Chronic Renal Failure.
- Author:
Jin A PARK
1
;
Mi Jung SHIN
;
Bok Jin HYOUNG
;
Hoon Suk PARK
;
Jung Min YOON
;
Beom Sun CHOE
;
Chul Woo YANG
;
Yong Soo KIM
;
Suk Young KIM
;
Byung Kee BANG
Author Information
1. Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. sooncb@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Verapamil;
Chronic renal insufficiency;
Acute toxic effects
- MeSH:
Atropine;
Bradycardia;
Dialysis;
Fluid Therapy;
Humans;
Hyperkalemia;
Hypotension;
Kidney Failure, Chronic*;
Renal Insufficiency, Chronic;
Verapamil*
- From:Korean Journal of Nephrology
2005;24(3):501-509
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Four hypertensive patients with chronic renal insufficiency who were treated with sustained release verapamil hydrochloride subsequently developed acute toxic effects. All four patients developed marked bradycardia, hypotension, hyperkalemia and metabolic aciodosis and were treated with atropine, fluid therapy, potasium lowing measure, dialysis, and temporary pacemaker, and were restored to the renal function and sinus rhythm after 12-24 hr. Patients with renal impairement who are treated with sustained release verapamil may accumulate verapamil or its metabolites and develop toxic side effects. We conclude that sustained release verapamil should be used with caution in chronic renal failure and that patients should be closely monitored for adverse cardiovascular, metaboic, and hepatic side effects.
