Apolipoprotein E and ACE genetic polymorphism and nephropathy in type 2 diabetic patients.
- Author:
Jong Suk PARK
1
;
Joo Young NAM
;
Chul Sik KIM
;
Dol Mi KIM
;
Min Ho CHO
;
Jina PARK
;
Chul Woo AHN
;
Bong Soo CHA
;
Sung Kil LIM
;
Kyung Rae KIM
;
Hyun Chul LEE
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. acw@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Apolipoprotein E (Apo E) gene;
Angiotensin-converting enzyme (ACE) gene;
Type 2 diabetes;
Diabetic nephropathy
- MeSH:
Apolipoprotein E2;
Apolipoprotein E3;
Apolipoprotein E4;
Apolipoproteins E;
Apolipoproteins*;
Diabetic Nephropathies;
Genotype;
Humans;
Odds Ratio;
Plasma;
Polymorphism, Genetic*;
Risk Factors
- From:Korean Journal of Medicine
2005;68(5):511-518
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The aim of this study was to investigate the association between apo E and ACE genetic polymorphism and diabetic nephropathy. METHODS: One hundred eighteen patients with type 2 diabetes who had a duration of diabetes longer than 8 years were divided into the three apo E groups (E2, E3, E4) and three ACE groups (II, ID, DD). Plasma levels of lipids were measured. The frequency of diabetic nephropathy and clinical and biochemical characteristics were compared among the Apo E and ACE genotype groups. RESULTS: The frequency of overt nephropathy was significantly greater in apo E2 patients with diabetes (46.7%) than apo E3 (16.7%) or apo E4 patients (10.5%). Logistical regression analysis showed that odds ratio of apo E2 and apo E4 genotypes for the presence of overt nephropathy were 4.779 (p<0.01) and 0.643 (p=0.583), respectively. Plasma TG levels were significantly greater in apo E2 patients. This study did not show an association between ACE gene polymorphism and diabetic nephropathy, and no interaction between Apo E and ACE gene polymorphism. CONCLUSION: Apo E2 is a prognostic risk factor for diabetic nephropathy in Korean type 2 diabetes. TG may have an important role of diabetic nephropathy. There were not synergistic effect between Apo E and ACE gene polymorphism in diabetic nephropathy.
