A case of intracranial hemorrhage in a neonate with congenital factor VII deficiency.
10.3345/kjp.2010.53.10.913
- Author:
Won Seok LEE
1
;
Young Sil PARK
Author Information
1. Department of Pediatrics, Kyung Hee University School of Medicine, Seoul, Korea. pysmd@khnmc.or.kr
- Publication Type:Case Report
- Keywords:
Congenital factor VII deficiency;
Intracranial hemorrhage;
Neonate
- MeSH:
Blood Coagulation Factors;
Factor VII;
Factor VII Deficiency;
Hemorrhage;
Humans;
Infant, Newborn;
Intracranial Hemorrhages;
Plasma;
Prothrombin
- From:Korean Journal of Pediatrics
2010;53(10):913-916
- CountryRepublic of Korea
- Language:English
-
Abstract:
Congenital factor VII deficiency is a rare autosomal-recessive bleeding disorder. Bleeding manifestations and clinical findings vary widely, ranging from asymptomatic subjects to patients with hemorrhages that may cause significant handicaps. Treatment has traditionally involved factor VII(FVII) replacement therapy using fresh frozen plasma, prothrombin complex concentrates or plasma-derived FVII concentrates. Recombinant activated FVII (NovoSeven(R)) is currently considered the first-line treatment for replacement therapy of FVII deficiency. Here we present a case of severe intracerebral and intraventricular hemorrhage in a neonate with congenital FVII deficiency.
