Risk Factors for Anxiety in Major Depressive Disorder Patients.
10.9758/cpn.2015.13.3.263
- Author:
Li Min XIN
1
;
Lin CHEN
;
Zhen Peng JI
;
Suo Yuan ZHANG
;
Jun WANG
;
Yan Hong LIU
;
Da Fang CHEN
;
Fu De YANG
;
Gang WANG
;
Yi Ru FANG
;
Zheng LU
;
Hai Chen YANG
;
Jian HU
;
Zhi Yu CHEN
;
Yi HUANG
;
Jing SUN
;
Xiao Ping WANG
;
Hui Chun LI
;
Jin Bei ZHANG
;
Tian Mei SI
Author Information
1. Peking University Sixth Hospital/Institute of Mental Health, National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), and the Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China. si.tia
- Publication Type:Original Article
- Keywords:
Depressive disorder;
Anxiety;
Risk factors
- MeSH:
Anxiety*;
Asian Continental Ancestry Group;
Bipolar Disorder;
Checklist;
China;
Depression;
Depressive Disorder;
Depressive Disorder, Major*;
Humans;
Logistic Models;
Mood Disorders;
Risk Factors*;
Seasons
- From:Clinical Psychopharmacology and Neuroscience
2015;13(3):263-268
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To analyze the sociodemographic and clinical factors related to anxiety in patients with major depressive disorder (MDD). METHODS: This study involved a secondary analysis of data obtained from the Diagnostic Assessment Service for People with Bipolar Disorders in China (DASP), which was initiated by the Chinese Society of Psychiatry (CSP) and conducted from September 1, 2010 to February 28, 2011. Based on the presence or absence of anxiety-related characteristics, 1,178 MDD patients were classified as suffering from anxious depression (n=915) or non-anxious depression (n=263), respectively. RESULTS: Compared with the non-anxious group, the anxious-depression group had an older age at onset (t=-4.39, p<0.001), were older (t=-4.69, p<0.001), reported more lifetime depressive episodes (z=-3.24, p=0.001), were more likely to experience seasonal depressive episodes (chi2=6.896, p=0.009) and depressive episodes following stressful life events (chi2=59.350, p<0.001), and were more likely to have a family history of psychiatric disorders (chi2=6.091, p=0.014). Their positive and total scores on the Mood Disorder Questionnaire (MDQ) and the 32-item Hypomania Checklist (HCL-32) (p<0.05) were also lower. The logistic regression analysis indicated that age (odds ratio [OR]=1.03, p<0.001), a lower total MDQ score (OR=0.94, p=0.011), depressive episodes following stressful life events (OR=3.04, p<0.001), and seasonal depressive episodes (OR=1.75, p=0.039) were significantly associated with anxious depression. CONCLUSION: These findings indicate that older age, fewer subclinical bipolar features, an increased number of depressive episodes following stressful life events, and seasonal depressive episodes may be risk factors for anxiety-related characteristics in patients with MDD.
