In situ tissue regeneration through host stem cell recruitment.
- Author:
In Kap KO
1
;
Sang Jin LEE
;
Anthony ATALA
;
James J YOO
Author Information
1. Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USA. jyoo@wakehealth.edu
- Publication Type:Review ; Research Support, Non-U.S. Gov't
- Keywords:
bioactive molecules;
biomaterials;
in situ tissue regeneration;
protein delivery system;
stem cells;
tissue engineering
- MeSH:
Animals;
Guided Tissue Regeneration/*methods;
Humans;
Stem Cell Transplantation/*methods;
Stem Cells/*cytology/metabolism;
Tissue Engineering/methods;
Tissue Scaffolds
- From:Experimental & Molecular Medicine
2013;45(11):e57-
- CountryRepublic of Korea
- Language:English
-
Abstract:
The field of tissue engineering has made steady progress in translating various tissue applications. Although the classical tissue engineering strategy, which involves the use of culture-expanded cells and scaffolds to produce a tissue construct for implantation, has been validated, this approach involves extensive cell expansion steps, requiring a lot of time and laborious effort before implantation. To bypass this ex vivo process, a new approach has been introduced. In situ tissue regeneration utilizes the body's own regenerating capacity by mobilizing host endogenous stem cells or tissue-specific progenitor cells to the site of injury. This approach relies on development of a target-specific biomaterial scaffolding system that can effectively control the host microenvironment and mobilize host stem/progenitor cells to target tissues. An appropriate microenvironment provided by implanted scaffolds would facilitate recruitment of host cells that can be guided to regenerating structural and functional tissues.
