Molecular Culprits Generating Brain Tumor Stem Cells.
- Author:
Se Yeong OH
1
;
Hyunggee KIM
Author Information
- Publication Type:Review
- Keywords: High-grade glioma; Brain tumor stem cell; Cancer stem cell niche; Brain tumor stem cell reprogramming; Reprogramming factors
- MeSH: Adult Stem Cells; Brain Neoplasms*; Brain*; Drug Therapy; Glioma; Humans; Radiotherapy; Recurrence; Stem Cells*
- From:Brain Tumor Research and Treatment 2013;1(1):9-15
- CountryRepublic of Korea
- Language:English
- Abstract: Despite current advances in multimodality therapies, such as surgery, radiotherapy, and chemotherapy, the outcome for patients with high-grade glioma remains fatal. Understanding how glioma cells resist various therapies may provide opportunities for developing new therapies. Accumulating evidence suggests that the main obstacle for successfully treating high-grade glioma is the existence of brain tumor stem cells (BTSCs), which share a number of cellular properties with adult stem cells, such as self-renewal and multipotent differentiation capabilities. Owing to their resistance to standard therapy coupled with their infiltrative nature, BTSCs are a primary cause of tumor recurrence post-therapy. Therefore, BTSCs are thought to be the main glioma cells representing a novel therapeutic target and should be eliminated to obtain successful treatment outcomes.
