Prognostic Factors in Liposarcomas: A Retrospective Study of 52 Patients.
10.5292/jkbjts.2010.16.1.14
- Author:
Yang Guk CHUNG
;
Yong Koo KANG
;
Won Jong BAHK
;
Seung Koo RHEE
;
An Hi LEE
;
Jung Mee PARK
;
Min Woo KIM
- Publication Type:Original Article
- Keywords:
liposarcomas;
local recurrence;
distant metastasis;
event-free survival;
prognostic factors
- MeSH:
Disease-Free Survival;
Extremities;
Follow-Up Studies;
Humans;
Liposarcoma;
Multivariate Analysis;
Neoplasm Metastasis;
Recurrence;
Retrospective Studies;
Selection Bias
- From:The Journal of the Korean Bone and Joint Tumor Society
2010;16(1):14-20
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To investigate prognostic factors influencing on local recurrence, distant metastasis and event-free survival of liposarcomas. MATERIALS AND METHODS: Fifty-two patients managed for liposarcomas since 1993 were analyzed respectively in the view of prognostic influence of patient age, tumor size, location, histologic type, histologic grade, resection type, surgical margin, chemotherapy and radiation therapy on local recurrence, distant metastasis and event-free survival. The mean follow up period was 39 months. The univariate and multivariate regression analysis were performed for statistical evaluation. RESULTS: The local recurrences occurred in 11 patients (21.2%) and distant metastasis in 4 patients (8%), Event-free survival rate at 4 year follow up was 67%. In univariate analysis, histologic grade, surgical margin, chemotherapy and radiation therapy were significant prognostic factors on local recurrence (p<0.05). However, histologic grade lost its significance in muitivariate analysis. Trunk location revealed higher rate of distant metastasis than extremity location. In univariate analysis on event-free survival. histologic grade and chemotherapy were significant factors (p<0.05). No factor remained significant in multivariate analysis. CONCLUSION: Considering selection bias, positive surgical margin was negative prognostic factor on local recurrence. Liposarcomas arisen in trunk revealed higher rate of distant metastasis. There was no independent prognostic factor on event-free survival of patients with liposarcomas.
