Expression of Osteopontin and Clusterin in Transitional Cell Carcinoma of the Bladder: Comparison to the Pathologic Stage.
- Author:
Jong Hyun YOON
1
;
Ju Han LEE
;
Bum Woo YEOM
;
Nam Hee WON
;
Duck Ki YOON
Author Information
1. Departments of Urology, Korea University College of Medicine, Seoul, Korea. dkyoon@korea. ac.kr
- Publication Type:Original Article
- Keywords:
Osteopontin;
Clusterin;
Bladder;
Transitional cell carcinoma
- MeSH:
Carcinoma, Transitional Cell*;
Clusterin*;
Osteopontin*;
Urinary Bladder*
- From:Korean Journal of Urology
2005;46(4):341-346
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This study was performed to evaluate the expressions of osteopontin (OPN) and clusterin in a transitional cell carcinoma (TCC) of the urinary bladder, and then compare their expression rates with the tumor invasiveness. MATERIALS AND METHODS: Twenty-five superficial and 25 invasive TCC were used for immunohistochemical staining. RESULTS: All 25 non-invasive TCC showed a strong positive reaction for OPN. Twenty of the invasive TCC showed a strong positive reaction for OPN, but 5 showed only a weak positive reaction. OPN expression was significantly decreased in the invasive TCC (p=0.02). Eighteen superficial TCC showed a weak positive reaction for clusterin, with 7 showing a negative reaction. Nine invasive TCC showed a strong positive reaction for clusterin, and 11 showed only a weak positive reaction. Five invasive TCC showed a negative reaction for clusterin. Clusterin expression was significantly increased in the invasive TCC (p=0.001). CONCLUSIONS: These results may suggest that OPN and clusterin could be used as markers to predict the biological behavior of a TCC.
