Two Cases of Antituberculosis Drug-induced Hypersensitivity Syndrome.
- Author:
Ho Joon YOON
1
;
Dong Hun LEE
;
Wan Sik SIN
;
Dae Hun SUH
Author Information
1. Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea. daehun@snu.ac.kr
- Publication Type:Case Report
- Keywords:
Antituberculosis drug;
Drug-induced hypersensitivity syndrome;
Human herpes virus-6
- MeSH:
Anticonvulsants;
DNA;
Humans;
Hypersensitivity*;
Polymerase Chain Reaction
- From:Korean Journal of Dermatology
2007;45(6):635-639
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Drug-induced hypersensitivity syndrome is a rare, but severe, life-threatening disease with multiorgan failure. Aromatic antiepileptic drugs are frequent causes of this syndrome. The association of the human herpes virus-6 has been recently reported in patients with drug-induced hypersensitivity syndrome. We report two patients who were diagnosed as having antituberculosis drug-induced hypersensitivity syndrome based on clinical course and laboratory data. In addition, human herpes virus-6 DNA was detected by polymerase chain reaction in peripheral blood mononuclear cells and the serum. There was a favorable outcome after discontinuation of the causative drug, plus corticosteroid therapy. After the treatment, human herpes virus-6 DNA was not detected by polymerase chain reaction. This is the first report of antituberculosis drug-induced hypersensitivity syndrome associated with reactivation of human herpes virus-6.
