Nutritional status and plasma amino acid profile in maintenance hemodialysis patients.
- Author:
Dong Jin YOUN
1
;
Jin Kook KIM
;
Soo Jeong CHOI
;
Tae Youn CHOI
;
Seung Duk HWANG
Author Information
1. Department of Internal Medicine, Sooncunhyang University Medical College, Buchon, Korea. sd7hwang@schbc.ac.kr
- Publication Type:Original Article
- Keywords:
Nutrition;
Dialysis;
Amino acids
- MeSH:
Acidosis;
Alanine;
Amino Acids;
Cholesterol;
Cystine;
Dialysis;
Diet;
Fasting;
Glutamine;
Glycine;
Histidine;
Humans;
Isoleucine;
Kidney;
Kidney Failure, Chronic;
Leucine;
Lysine;
Malnutrition;
Metabolism;
Methionine;
Nitrogen;
Nutritional Status*;
Plasma*;
Prealbumin;
Proline;
Renal Dialysis*;
Serine;
Serum Albumin;
Transferrin;
Triglycerides;
Uremia;
Valine
- From:Korean Journal of Medicine
2002;62(5):522-529
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Many studies document the presence of abnormalities in amino acids metabolism in chronic uremia. These abnormalities have been attributed to low protein intake, deficiency of excretory and metabolic functions of the diseased kidneys, toxic effects of uremia on the intermediary metabolism of amino acids and in dialysis patients, loss of protein and amino acids by the dialytic procedure. METHODS: This study was designed to compare anthropometric measurement, biochemical characteristics and plasma amino acid concentration between patients with end stage renal disease on maintenance hemodialysis (HD) and normal controls. A cross sectional study of overnight fasting plasma amino acids and plasma albumin, prealbumin, triglyceride (TG), cholesterol, transferrin concentration were performed on 20 hemodialysis patients and 20 normal controls, matched by age and sex. RESULTS: The concentrations of prealbumin (25.60+/-7.05 mg/dL vs 35.08+/-8.11 mg/dL, p<0.005), transferrin (158.30+/-39.66 mg/dL vs 275.50+/-55.46 mg/dL, p<0.001) were found to be lower in HD patients. No differences in albumin, cholesterol and TG were observed between the two groups. Several amino acids (taurine, cystine, phosphoserine) were found to be higher in the HD patients, while the concentrations of other five amino acids (serine, alanine, valine, leucine, tyrosine) were lowered in HD patients. No differences in nine amino acids (asparagine, glutamine, proline, glycine, methionine, isoleucine, lysine, histidine, arginine) were observed between the two groups. CONCLUSION: Our results suggest that chronic renal failure patients have malnutrition and amino acids abnormalities. To correct the amino acids abnormalities and improve nitrogen utilization in hemodialysis patients, correction of acidosis and supplementation of the diet with serine should be considered.
