The endothelin-1 expression in the kidney tissue of patients with glomerulonephritis.
- Author:
Sung Jin BAE
1
;
Won Suk AN
;
Suh Hee RHA
;
Seong Eun KIM
;
Ki Hyun KIM
Author Information
1. Department of Internal Medicine, Dong-A Univeristy College of Medicine, Pusan, Korea. sekim@mail.donga.ac.kr
- Publication Type:Original Article
- Keywords:
Endothelin-1;
Glomerulonephritis
- MeSH:
Biopsy;
Endothelin-1*;
Endothelium;
Endothelium, Vascular;
Epithelium;
Glomerulonephritis*;
Glomerulonephritis, Membranoproliferative;
Humans;
Immunoglobulin A;
Kidney*;
Mesangial Cells;
Nephrosis, Lipoid
- From:Korean Journal of Medicine
2002;62(5):530-536
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Endothelin-1 has been found to be a potent mitogen in cultured mesangial cells. In addition, the urinary hyperexcretion of endothelin-1 was observed in patients with glomerulonephritis. METHODS: The author studied endothelin-1 immunoreactivity in 64 kidney biopsies of patients with various glomerular diseases by immunoperoxidase staining utilizing anti-endothelin-1 serum from the rabbit. RESULTS: A group of Ig A nephropathy with glomerular proliferative change (8 focal glomerulonephritis and 7 diffuse mesangial proliferative glemerulonephritis) and a group of other proliferative glomerulonephritis (11 membranoproliferative glomerulonephritis type I, 5 poststreptococcal glomerulonephritis, 8 focal or diffuse proliferative lupus nephritis) have more prominent endothelin-1 protein expression in the glomerular endothelium, the vascular endothelium and the tubular epithelium than non-proliferative glomerular disease group (12 minimal change nephrotic syndrome, 7 membranous nephropathies, 6 IgA nephropathies with minor glomerular abnormality). CONCLUSION: These results suggest that endothelin-1 has a potential role in the pathophysiology of proliferative glomerualr diseases.
