Appearance of osteoporosis in rat experimental autoimmune encephalomyelitis.
10.14405/kjvr.2016.56.2.117
- Author:
Meejung AHN
1
;
Sohi KANG
;
Channam PARK
;
Jeongtae KIM
;
Kyungsook JUNG
;
Miyoung YANG
;
Sung Ho KIM
;
Changjong MOON
;
Taekyun SHIN
Author Information
1. School of Medicine, College of Veterinary Medicine, Jeju National University, Jeju 63243, Korea. healthy@jejunu.ac.kr
- Publication Type:Brief Communication
- Keywords:
autoimmunity;
experimental autoimmune encephalomyelitis;
micro-computed tomography;
osteoporosis
- MeSH:
Animals;
Autoimmunity;
Bone Density;
Encephalomyelitis, Autoimmune, Experimental*;
Hindlimb;
Inflammation;
Osteoporosis*;
Paralysis;
Rats*;
Tibia
- From:Korean Journal of Veterinary Research
2016;56(2):117-120
- CountryRepublic of Korea
- Language:English
-
Abstract:
Experimental autoimmune encephalomyelitis (EAE) in Lewis rats is characterized by transient paralysis followed by recovery. To evaluate whether transient paralysis in EAE affects bone density, tibiae of EAE rats were morphologically investigated using micro-computed tomography and histology. The parameters of bone health were significantly reduced at the peak stage of EAE rats relative to those of controls (p < 0.05). The reduction of bone density was found to remain unchanged, even in the recovery stage. Collectively, the present data suggest that osteoporosis occurs in paralytic rats with monophasic EAE, possibly through the disuse of hindlimbs and/or autoimmune inflammation.
