A case of combined deficiency of antithrombin III and protein C complicated by recurrent venous thrombosis.
- Author:
Min Sup EUM
1
;
Yeon Hee PARK
;
Jae Il SEOL
;
Soo Youb CHAE
;
Moon Bin YOU
;
Ki Hoon KANG
;
Byung Soo LEE
;
Chae Eun HA
;
Jeong Sik PARK
;
Yong Hwan JUNG
;
Seung Hye AHN
;
Hyo Jin LEE
Author Information
1. Department of Internal Medicine, Seoul Adventist Hospital, Seoul, Korea. js36park@hanmail.net
- Publication Type:Case Report
- Keywords:
Venous thrombosis;
Antithrombin III;
Protein C
- MeSH:
Adult;
Antithrombin III*;
Humans;
Jejunum;
Mesenteric Veins;
Necrosis;
Protein C*;
Protein S;
Pulmonary Embolism;
Recurrence;
Thrombosis;
Venous Thrombosis*;
Warfarin
- From:Korean Journal of Medicine
2002;62(5):570-574
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Primary venous thrombosis caused by deficiency or qualitative abnormality of antithrombin III, protein C and protein S is usually inherited as an autosomal dominant trait. Usually, deep vein thrombosis or pulmonary thromboembolism is developed by such abnormalities, however, mesenteric vein thrombosis is rarely reported. A 27-year-old man with previous history of deep vein thrombosis underwent segmental resection of jejunum due to mesenteric vein thrombosis complicated by necrosis of jejunum. Postoperative investigation disclosed combined deficiency of antithrombin III and protein C. His son also showed deficiency of antithrombin III. Postoperatively, he is on life-long warfarin therapy without experiencing recurrence of venous thrombosis.
