Changes in serum uric acid levels after allogeneic hematologic stem cell transplantation: A retrospective cohort study.
- Author:
Sang Hyun JOO
1
;
Jin Kyun PARK
;
Eunyoung Emily LEE
;
Yeong Wook SONG
;
Sung Soo YOON
Author Information
- Publication Type:Original Article
- Keywords: Uric acid; Hematopoietic stem cell transplantation; Bone marrow
- MeSH: Anemia, Aplastic; Bone Marrow; Cohort Studies*; Hematopoietic Stem Cell Transplantation; Hematopoietic System; Humans; Hyperuricemia; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Prevalence; Retrospective Studies*; Stem Cell Transplantation*; Stem Cells*; Tissue Donors; Transplants; Uric Acid*
- From:Blood Research 2016;51(3):200-203
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Since cell turnover in the hematopoietic system constitutes a major source of uric acid (UA) production, we investigated whether hematopoietic stem cell transplantation (HSCT) is associated with significant changes in serum UA levels in patients with hematological disorders. METHODS: Patients who underwent HSCT at our institution between 2001 and 2012 were retrospectively enrolled. Serum UA levels at 3 months before, 1 week before, and 3 months and 1 year after HSCT were examined. RESULTS: Complete clinical and laboratory information including data regarding UA levels was available for 93 patients. At baseline, the mean UA level was 4.9±2.1 mg/dL, with an overall prevalence of hyperuricemia of 15% (defined as serum UA>6.8 mg/dL). Mean UA levels tended to be higher in patients with acute myeloid leukemia (4.8±2.0 mg/dL) and non-Hodgkin lymphoma (5.1±2.3 mg/dL) and lower in patients with aplastic anemia (mean, 4.2±1.8 mg/dL). UA levels dropped during myeloablative conditioning, reaching a nadir on the day of HSCT (3.27±1.4 mg/dL). Over the 3 months following HSCT, UA levels rose sharply (5.0±2.1 mg/dL) and remained stable up to 1 year after HSCT (5.5±1.6 mg/dL). UA levels in HSCT recipients at 12 months correlated with those of their respective graft donors (Pearson r=0.406, P=0.001). CONCLUSION: HSCT is associated with significant changes in uric acid levels in patients with hematologic disorders.
