A Case of Hyperkalemic Periodic Paralysis Induced by Diabetic Nephropathy.
- Author:
Chang Seog LEE
1
;
Jung Min PARK
;
Min Seong KIM
;
Ju Ho LEE
;
Do Young KIM
;
Young Bae LIM
;
Yong Kyu LEE
Author Information
1. Department of Internal Medicine, Good Gang-An Hospital, Busan, Korea. lyk59@medimail.co.kr
- Publication Type:Case Report
- Keywords:
Diabetic Nephropathy;
Hyperkalemic Periodic;
Paralysis
- MeSH:
Adrenal Insufficiency;
Diabetic Nephropathies;
Dietary Sucrose;
Hyperkalemia;
Hypoaldosteronism;
Muscle, Skeletal;
Neural Conduction;
Paralysis;
Paralysis, Hyperkalemic Periodic;
Point Mutation;
Potassium;
Renal Insufficiency;
Sequence Analysis, DNA;
Sodium Channels;
Uncertainty
- From:Korean Journal of Medicine
2011;80(Suppl 2):S227-S232
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hyperkalemic periodic paralysis is characterized by episodic flaccid paralysis of the skeletal muscles due to an increase in serum potassium concentrations. Primary hyperkalemic periodic paralysis is caused by point mutations in SCN4A, encoding a voltage-gated skeletal muscle sodium channel. However, hyperkalemia-related diseases, such as renal failure, adrenal insufficiency, hypoaldosteronism, and chronic diuretic use, can induce secondary hyperkalemic periodic paralysis. Diagnosis of this disease is based on clinical features, nerve conduction studies, and a DNA sequence analysis. In cases of diagnostic uncertainty, a provocation test can be used to ensure the correct diagnosis. Here, we report a case of secondary hyperkalemic periodic paralysis with hyperkalemia that was induced by diabetic nephropathy, and review the relevant literature.
