A case of immediate hypersensitivity to cefaclor: serum specific IgE detection.
- Author:
Jeong Hee CHOI
1
;
Yu Jin SUH
;
Yu Seob SHIN
;
Chang Hee SUH
;
Dong Ho NAHM
;
Hae Sim PARK
Author Information
1. Department of Allergy-Rheumatology, Ajou University School of Medicine, Suwon, Korea. hspark@madang.ajou.ac.kr
- Publication Type:Original Article
- Keywords:
anaphylaxis;
cefaclor;
specific IgE
- MeSH:
Adult;
Anaphylaxis;
Angioedema;
beta-Lactams;
Blood Pressure;
Cefaclor*;
Cephalosporins;
Dyspnea;
Edema;
Enzyme-Linked Immunosorbent Assay;
Heel;
Humans;
Hypersensitivity;
Hypersensitivity, Immediate*;
Immunoglobulin E*;
Osteomyelitis;
Penicillins;
Serum Albumin;
Skin;
Urticaria
- From:Journal of Asthma, Allergy and Clinical Immunology
2003;23(2):414-419
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Cephalosporines are the most important beta-lactams inducing IgE-mediated reactions such as urticaria, angioedema and anaphylaxis. There have been a few reports that describes assays of serum specific IgE for cephalosporins. We experienced a case of cefaclor-induced anaphylaxis and detected serum specific IgE to cefalor-human serum albumin (HSA) conjugate. A 40-year-old man was hospitalized due to sudden dyspnea. generalized urticaria, facial edema 30 minutes after taking cefaclor (250mg, po) for an upper respiratory infection. His systolic blood pressure dropped to 50 mmHg at admission. He had been treated with cefaclor for chronic osteomyelitis of the right heel for 1 year without adverse reactions. He had no personal or family history of allergic disease nor penicillin hypersensitivity. Skin prick test with cefaclor showed a positive response and serum specific IgE to cefaclor-HSA conjugate was detected by ELISA inhibition test showed significant inhibitions with additions of cefaclor-HSA conjugate and cefaclor in a dose-dependent manner. In conclusion, we confirmed that cefaclor-induced anaphylaxis in this patient was an IgE-mediated reation to cefaclor-HSA conjugate.
