Complete Blood Count Reference Values of Donated Cord Blood from Korean Neonates.
10.3343/kjlm.2009.29.3.179
- Author:
Hye Ryun LEE
1
;
Sue SHIN
;
Jong Hyun YOON
;
Byoung Jae KIM
;
Kyu Ri HWANG
;
Jin Ju KIM
;
Eun Youn ROH
Author Information
1. Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea. 75-crimson@hanmail.net
- Publication Type:Original Article ; English Abstract
- Keywords:
Donated cord blood;
Reference value;
CBC
- MeSH:
Blood Cell Count/*standards;
Female;
Fetal Blood/*cytology;
Humans;
Infant, Newborn;
Korea;
Male;
Reference Values
- From:The Korean Journal of Laboratory Medicine
2009;29(3):179-184
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: In the public cord blood (CB) banks, only safe CB units with adequate cell doses are processed and stored. Complete blood count (CBC) of CB is crucial for estimating total nucleated cells (TNC) and screening suitable CB units without hematologic abnormalities. We analyzed CBC parameters of the donated CB from healthy Korean neonates to establish CBC reference values. METHODS: A total of 2,129 Korean CB units, donated and processed during the period from August 2007 to December 2007, were enrolled. We measured hemoglobin (Hb), white blood cell (WBC) count, differential count of WBC, platelets and nucleated red blood cell (nRBC) count by XE-2100 automated hematology analyzer (Sysmex, Japan), and estimated reference value of each parameter by using parametric (Mean+/-2SD) and/or non-parametric methods (2.5-97.5 percentile). And also, we compared the result of each parameter in relation to sex of neonates and delivery method. RESULTS: Because the differences of CBC values among different subgroups were not remarkable, we established the reference intervals as follows without subgroup division: Hb, 9.0-14.4 g/dL; WBC count, 5.6-18.5x103/microL; differential count of WBC (neutrophils, 40.8-72.4%; lymphocytes, 17.2-46.7%; monocytes, 4.9-12.8%; eosinophils, 0.7-7.0%; basophils, 0.0-1.6%); platelet, 130-287x103/microL; nRBCs, 0.0-13.1/100 WBC. CONCLUSIONS: We established cord blood CBC reference values of healthy Korean neonates using a large-scale CB units. The established CBC reference values from our study will be useful as basic data for CBC interpretation and assessment of transplant suitability of donated CB.
