A Novel Translocation t(1;5)(p32;q31) that Was Not Associated with the TAL1 Rearrangement in a Case of T Lymphoblastic Leukemia/Lymphoma.
10.3343/kjlm.2009.29.3.199
- Author:
Hee Soon CHO
1
;
Min Kyoung KIM
;
Young Kyung BAE
Author Information
1. Department of Laboratory Medicine, Yeungnam University College of Medicine, Daegu, Korea. chscp@med.yu.ac.kr
- Publication Type:Case Report
- Keywords:
T-ALL;
t(1;
5)(p32;
q31);
TAL1 gene
- MeSH:
Basic Helix-Loop-Helix Transcription Factors/*genetics/metabolism;
Bone Marrow/pathology;
Chromosomes, Human, Pair 1;
Chromosomes, Human, Pair 5;
Humans;
Karyotyping;
Male;
Middle Aged;
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/*diagnosis/genetics/pathology;
Proto-Oncogene Proteins/*genetics/metabolism;
Tomography, X-Ray Computed;
*Translocation, Genetic
- From:The Korean Journal of Laboratory Medicine
2009;29(3):199-203
- CountryRepublic of Korea
- Language:English
-
Abstract:
Chromosome 1 band p32 (1p32) aberrations are common in T lymphoblastic leukemia/lymphoma (T-ALL/LBL). Two types of 1p32 aberrations include translocations with different partners and submicroscopic interstitial deletion. Both aberrations are known to result in TAL1 gene deregulation. The t(1;5)(p32;q31) is a rare translocation of 1p32 in T-ALL. We now present the second case of t(1;5)(p32;q31) in T-ALL, which was present as a primary cytogenetic abnormality, with a review of the relevant literature. Interestingly, neither the translocation of the TAL1 gene nor aberrant expression of TAL1 protein was detected by fluorescent in situ hybridization (FISH) and by immunohistochemical staining in this case.
