The Expression of Multiple Proteins as Prognostic Factors in Colorectal Cancer: Cathepsin D, p53, COX-2, Epidermal Growth Factor Receptor, C-erbB-2, and Ki-67.
- Author:
Il Yong SHIN
1
;
Na Young SUNG
;
Youn Soo LEE
;
Taek Soo KWON
;
Yoon SI
;
Yoon Suk LEE
;
Seong Taek OH
;
In Kyu LEE
Author Information
1. Department of Surgery, Yeouido St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea. cmcgslee@catholic.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Cathepsin D;
Prognostic factors;
Colorectal neoplasms
- MeSH:
Adenocarcinoma/*pathology;
Adenocarcinoma, Mucinous/pathology;
Adult;
Aged;
Cathepsin D/analysis;
Colorectal Neoplasms/*pathology;
Cyclooxygenase 2/analysis;
Female;
Humans;
Ki-67 Antigen/analysis;
Male;
Middle Aged;
Prognosis;
Receptor, Epidermal Growth Factor/analysis;
Receptor, ErbB-2/analysis;
Survival Analysis;
Tumor Markers, Biological/*analysis;
Tumor Suppressor Protein p53/analysis
- From:Gut and Liver
2014;8(1):13-23
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: A single gene mutation alone cannot explain the poor prognosis of colorectal cancer. This study aimed to establish a correlation between the expression of six proteins and the prognosis of colorectal cancer patients. METHODS: Tissue samples were collected from 266 patients who underwent surgery for colorectal cancer at our institution from January 2006 to December 2007. The expression of six proteins were determined using immunohistochemical staining of specimens. RESULTS: Cathepsin D, p53, COX-2, epidermal growth factor receptor, c-erbB-2, and Ki-67 expression were detected in 38.7%, 60.9%, 37.6%, 35.7%, 30.1%, and 74.4% of the samples, respectively. The expression of cathepsin D was significantly correlated with reduced cancer-free survival (p=0.036) and colorectal cancer-specific survival (p=0.003), but the other expression levels were not. In a multivariate analysis, cathepsin D expression was found to be an independent prognostic factor for poorer colorectal cancer-specific survival (hazard ratio, 8.55; 95% confidence interval, 1.07 to 68.49). Furthermore, patients with tumors expressing four or more of the proteins had a significantly decreased cancer-free survival rate (p=0.006) and colorectal cancer-specific survival rate (p=0.002). CONCLUSIONS: Patients with cathepsin D positivity had a poorer outcome than patients who were cathepsin D-negative. Thus, cathepsin D may provide an indicator for appropriate intensive follow-up and adjuvant chemotherapy.
